Rossjohn LabRecent Publications:
Florence WC, Xia C, Gordy LE, Chen W, Zhang Y, Scott-Browne J, Kinjo Y, Yu KO, Keshipeddy S, Pellicci DG, Patel O, Kjer-Nielsen L, McCluskey J, Godfrey DI, Rossjohn J, Richardson SK, Porcelli SA, Howell AR, Hayakawa K, Gapin L, Zajonc DM, Wang PG, Joyce S.
EMBO J. 2009 Oct 8
Structure and Function of the Oxidoreductase DsbA1 from Neisseria meningitidis.
Vivian JP, Scoullar J, Rimmer K, Bushell SR, Beddoe T, Wilce MC, Byres E, Boyle TP, Doak B, Simpson JS, Graham B, Heras B, Kahler CM, Rossjohn J, Scanlon MJ.
J Mol Biol. 2009 Oct 5
Here we describe how an enzyme from Neisseria meningitidis – the causative agent of epidemic meningitis – functions.
Post-translationally modified T cell epitopes: immune recognition and immunotherapy.
Petersen J, Purcell AW, Rossjohn J
J Mol Med. 2009 Sep 8
Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors.
Pellicci DG, Patel O, Kjer-Nielsen L, Pang SS, Sullivan LC, Kyparissoudis K, Brooks AG, Reid HH, Gras S, Lucet IS, Koh R, Smyth MJ, Mallevaey T, Matsuda JL, Gapin L, McCluskey J, Godfrey DI, Rossjohn J.
Immunity. 2009 Jul 17
T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire.
Mallevaey T, Scott-Browne JP, Matsuda JL, Young MH, Pellicci DG, Patel O, Thakur M, Kjer-Nielsen L, Richardson SK, Cerundolo V, Howell AR, McCluskey J, Godfrey DI, Rossjohn J, Marrack P, Gapin L.
Immunity. 2009 Jul 17
Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.
Beddoe T, Chen Z, Clements CS, Ely LK, Bushell SR, Vivian JP, Kjer-Nielsen L, Pang SS, Dunstone MA, Liu YC, Macdonald WA, Perugini MA, Wilce MC, Burrows SR, Purcell AW, Tiganis T, Bottomley SP, McCluskey J, Rossjohn J.
Immunity. 2009 Jun 19
The structure of the bacterial oxidoreductase enzyme DsbA in complex with a peptide reveals a basis for substrate specificity in the catalytic cycle of DsbA enzymes.
Paxman JJ, Borg NA, Horne J, Thompson PE, Chin Y, Sharma P, Simpson JS, Wielens J, Piek S, Kahler CM, Sakellaris H, Pearce M, Bottomley SP, Rossjohn J, Scanlon MJ.
J Biol Chem. 2009 Jun 26
Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains.
Williams NK, Bamert RS, Patel O, Wang C, Walden PM, Wilks AF, Fantino E, Rossjohn J, Lucet IS.
J Mol Biol. 2009 Mar 20
Crystal structure of LipL32, the most abundant surface protein of pathogenic Leptospira spp.
Vivian JP, Beddoe T, McAlister AD, Wilce MC, Zaker-Tabrizi L, Troy S, Byres E, Hoke DE, Cullen PA, Lo M, Murray GL, Adler B, Rossjohn J.
Mol Biol. 2009 Apr 17
Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes.
Petersen J, Wurzbacher SJ, Williamson NA, Ramarathinam SH, Reid HH, Nair AK, Zhao AY, Nastovska R, Rudge G, Rossjohn J, Purcell AW.
Proc Natl Acad Sci U S A. 2009 Feb 24
A long, naturally presented immunodominant epitope from NY-ESO-1 tumor antigen: implications for cancer vaccine design.
Ebert LM, Liu YC, Clements CS, Robson NC, Jackson HM, Markby JL, Dimopoulos N, Tan BS, Luescher IF, Davis ID, Rossjohn J, Cebon J, Purcell AW, Chen W.
Cancer Res. 2009 Feb 1
The shaping of T cell receptor recognition by self-tolerance.
Gras S, Burrows SR, Kjer-Nielsen L, Clements CS, Liu YC, Sullivan LC, Bell MJ, Brooks AG, Purcell AW, McCluskey J, Rossjohn J.
Immunity. 2009 Feb 20
The peptide length specificity of some HLA class I alleles is very broad and includes peptides of up to 25 amino acids in length.
Bell MJ, Burrows JM, Brennan R, Miles JJ, Tellam J, McCluskey J, Rossjohn J, Khanna R, Burrows SR.
Mol Immunol. 2009 May
Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition.
Archbold JK, Macdonald WA, Gras S, Ely LK, Miles JJ, Bell MJ, Brennan RM, Beddoe T, Wilce MC, Clements CS, Purcell AW, McCluskey J, Burrows SR, Rossjohn J.
J Exp Med. 2009 Jan 16