Recent Papers: Structure of a perforin-like protein reveals homology with bacterial cytolysins. ( Rosado CJ et al., Science )
The Whisstock laboratory focuses on the role of proteases and their inhibitors in degenerative disease and bacterial pathogenesis.
Primary techniques used within the lab are structural biology, bioinformatics together with molecular cell biology and biochemistry.
Current research directions include understanding how proteases function in the nucleus, probing the role of prokaryote serpins, and investigating how proteases function as virulence factors.
Bioinformatic research includes MUSTANG, a program for multiple structural alignment, PoPs - a program to predict protease substrate specificity, a database of single amino acid repeats, and CLIMS, a Laboratory Information Management system for crystallography.
The lab is supported by an NHMRC Program grant on protease systems biology, as well as the ARC Centre of Excellence on Structural and Functional Microbial Genomics.
Recent structures solved by our laboratory include MENT, a chromatin remodelling protease inhibitor and thermopin, the first structure of a prokaryote serpin, and the first structure of a MacPF domain.
Recent Bioinformatic successes include understanding how single amino acid repeats evolve (Faux et al., 2005, Genome Research).